Some people aren't cut out to play poker or blackjack. Both games put a little bit of pressure on you to be intelligent about which decisions you make. For those people, playing slots is a better option. You can have fun, gamble, earn comps, and relax. You don't have to worry about someone laughing at you for making a bad decision at a slot machine.
But suppose you're going to Vegas, and you're not sure where to play slot machines? A big part of deciding where to play the slots involves a little bit of self-analysis. What's important to you about a casino experience? Do you want to eat at a great buffet? Do you want to see shows at the same casino where you're playing slots? Or are you just looking for great odds and loose machines?
I can tell you the worst place to play slots in Las Vegas without even doing any research--the airport. The slot machines at the airport in Vegas are notoriously tight. I saw one survey (from about ten years ago) that indicated you could only expect an 85% payout percentage at the airport. Heck, you can get better odds playing roulette. (If the payout percentage is 85%, then the house edge is a whopping 15%!)
If you're looking for a good odds on roulette, blackjack, or craps, then the higher dollar rooms at the more expensive casinos usually cater to you. But with slots, the opposite is true, especially if you're a penny or nickel player. You'll find better slot machine payouts at casinos like Circus Circus than you will at the Venetian.
One reasonably nice hotel and casinos that offers decent slot payouts is the Hard Rock. It's not the most luxurious hotel or casino in Vegas, but the payouts on the slots are a reasonable amount compared to most other casinos of the same quality.
If you don't care about the payout percentages, and you're just interested in staying at the most luxurious hotel, then consider staying at the Wynn. It's probably as nice a hotel as you'll find in Vegas. I couldn't find any information about the Wynn's slots payout percentages, because the property is still too new. But if you can afford to stay there, you can afford to give up a few percentage points on the slot payback.
A more moderate choice that's still pretty luxurious is the MGM Grand. Another option would be the Bellagio. Both of these hotels are wonderful places to play slots, and the rooms are a terrific value too.
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